About... Cerebral Function / Emotional Well-Being Formulas

5-HTP

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Serotonin precursor for sleep, mood, nerve irritation, and appetite regulation

Product # 8101

30 capsules

gelatin

Product # 8102

90 capsules

gelatin

5-Hydroxytryptophan, or 5-HTP, is the direct precursor to serotonin, an important neurotransmitter that participates in the regulation of emotional moods, sleep/wake cycles, nerve thresholds, and appetite. Extracted from plant sources (Griffonia simplicifolia), 5-HTP is a natural alternative to synthetic L-tryptophan, which is now available by prescription only. In addition to increasing serotonin levels, 5-HTP causes an increase in levels of endorphins and other neurotransmitters that may be low in some clinical situations. Serotonin is an important initiator of sleep, and 5-HTP has been studied for many positive benefits with sleeplessness. Research also suggests increased serotonin levels may promote early satiety for appetite regulation.

• 5-HTP was superior to placebo in relieving discomfort and other symptoms associated with chronic muscle syndromes (J Int Med Res 1990;18:201–9).
• In several studies, 5-HTP was superior to placebo for stabilizing vascular and nerve irritability in the structures in and around the head (Headache 2000;40:451–6; Clin J Pain 1986;3:123–9).
• 5-HTP has mood-stabilizing properties demonstrated in controlled studies (Psychopathology 1991;24:53-81; Neuropsychobiology 1988;20:28-35).
• 5-HTP was superior to placebo for improving the depth and duration
  of sleep in one study (Schweiz Bundschau Med (PRAXIS) 1998;77(34a):19-23).
• 5-HTP helped control appetite and improved weight-loss results in three controlled trials (Am J Clin
  Nutr 1992;56:863-867; J Neural Transmission 1989;76:109-117; Adv Exp Med Biol 1991;294:591-3).

Supplement Facts Serving Size - 1 capsule Servings per container 30 or 90
Amount per serving:		%DV
5-Hydroxytryptophan (Griffonia simplicifolia)	100 mg	†
† Daily Value (DV) not established

Caution: Not appropriate for pregnant or lactating women. This product should not be combined with antidepressant medication.

Suggested use for adults:

• One capsule per day, before a meal or at bedtime, or as directed.

Feverfew

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Standardized feverfew for normal cerebral blood vessel tone

Product # 5201

30 capsules

Feverfew herb contains chemical components with significant prostaglandin and serotonin-modifying effects on cerebral vasomotor and nerve activity. Dried whole feverfew leaf standardized for parthenolide content has been repeatedly shown to help preserve normal vascular tone and neuronal sensitivity in the structures in and around the head.

• Standardized feverfew leaf extract contains the active constituent parthenolide, which has been shown to maintain normal blood vessel tone by reducing the release of serotonin from platelets (Lancet 1985;1:1071-4).
• Feverfew inhibits the production and release of inflammatory chemicals such as prostaglandins and arachidonic acid (Prostagland Leukotrienes Med 1982;8:653-60).
• In addition to controlling platelet serotonin secretion, feverfew has been shown to reduce platelet aggregation (J Pharm Pharmacol 1990;42:553-7).
• Controlled clinical research has found feverfew effective for stabilizing cerebral vasomotor and nerve overactivity associated with certain musculoskeletal complaints (Cephalagia 1998;18:704-8).

Supplement Facts Serving Size - 1 capsule Servings per container 30
Amount per serving:		%DV
Feverfew (Tenacetum parthenium)	100 mg	†
† Daily Value (DV) not established

Other ingredients: vegetarian capsule, vegetable stearate (food grade)

Caution: Not appropriate for pregnant or lactating women.

Suggested use for adults:

• One capsule daily, with water, or as directed.

Ginkgo

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Standardized extract for support of memory function and healthy circulation

Product # 5202

60 capsules

Ginkgo biloba is an ancient plant whose constituents have numerous beneficial effects on nerve tissue and circulation. Support by Ginkgo biloba extract (GBE) for normal brain function is based on neuroprotective effects against agents that can promote neuronal degeneration as well as regulating effects on neuro–transmitters. Research also shows GBE to have profound effects on circulation through inhibition of platelet activating factor (PAF) and other mediators of blood viscosity. GBE has been demonstrated to promote cerebrovascular and peripheral vascular circulation, enhancing blood flow, glucose delivery and oxygenation throughout the body, especially to the brain and nerve cells. Karuna’s Ginkgo biloba extract (GBE) is standardized identically to specifications for extracts used in clinical trials.

• Ginkgo contains two important constituent groups – the ginkgo flavone glycosides and the terpene lactones.
• Ginkgo biloba's flavone glycosides act as potent free radical scavengers within the cardiovascular and central nervous systems (Life Sci 2000;67: 1389-96; Phytomedicine 1998;5:425-34).
• Ginkgo is well-known for its neuro-protective properties (Zeitschrift Phytother 1994;15:92-6) and its support of normal cerebral functions such as memory (Phytomedicine 2000;6:393-401; Lancet 1992;340: 1136-1139).
• Ginkgo biloba inhibits platelet activating factor (PAF) which, in excess, can contribute to imbalances in leukocyte activity, bronchial function, and circulatory supply to body tissues (Thromb Res 2002;108: 151-60; Arzneimittelforschung 1990;40:589–93).
• Ginkgo promotes normal circulation (Fortschr Med 1993;111 (10):170-2) and can increase pain-free walking ability in older patients with impaired circulation (Am J Med 2000;108:276-81).

Supplement Facts Serving Size - 1 capsule Servings per container 60
Amount per serving:		%DV
Ginkgo biloba Extract**	60 mg	†
† Daily Value (DV) not established

** Standardized from 20-24% ginkgo flavone glycosides and 6% terpene lactones

Other ingredients: vegetarian capsule, rice flour

Suggested use for adults:

• One capsule twice daily with morning and evening meals, or as directed.

Melatonin

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Natural support for optimal body rhythms and sleep

Product # 8107

60 capsules

The body’s natural melatonin production (which declines with age) is responsible for setting the internal “clock” that governs the timing of neuroendocrine functions and other physiological processes. Melatonin has been shown to regulate circadian rhythms and clinically has been used to facilitate adjustment to changing time zones, stabilize mood during seasonal variations in sunlight availability, and to improve sleep.

• Melatonin production is known to decline with the aging process (BMJ 1994;309:167).
• Melatonin is effective for helping to promote natural, restful sleep in both younger (Sleep 1998;21:52-68) and older (J Am Geriatr Soc 1996; 44:51) people.
• Melatonin supplementation has helped reduce the discomfort associated with changing time zone
  in controlled trials (Chronobiol Int 1998;15:655-66; Biol Psychiatry 1992;32:705-11).
• Melatonin helped stabilize mood during the winter months in one controlled trial (Psychiatr Res 1998;77:57–61).
  

Supplement Facts Serving Size - 1 capsule Servings per container 60
Amount per serving:		%DV
Melatonin	3 mg	†
† Daily Value (DV) not established

Caution: Not appropriate for pregnant or lactating women.

Suggested use for adults:

• One tablet, one hour before bedtime, or as directed.

MemoRegen

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Powerful neurorestorative and cognition-enhancing formula.

Product # 9128

60 capsules

Many middle-aged and older individuals struggle with changes in memory and other brain functions. Several natural compounds have shown outstanding promise and safety for supporting good cognitive function. Ginkgo biloba standardized extract (GBE) has been the subject of the greatest amount of research in this regard, but the several additional ingredients of MemoRegen provide even more unique and valuable properties for optimizing memory and other brain functions.

• Ginkgo biloba standardized extract (GBE) has been shown in human trials to have a significant effect on cognitive function in elderly individuals (Arch Neurol 1998;55: 1409-15).
• Acetyl-L-Carnitine is an important provider of acetyl groups for synthesis of acetylcholine (Mol Psychiatry 2000; 5:616-32) and promotes the release of this cognitive neurotransmitter (N Engl J Med 1999;341:1670-9).
• Acetyl-L-Carnitine is an antioxidant with specific protective activity against oxidative stress in the brain (Ann N Y Acad Sci 2004;1033:117-31).
• Huperzine A, a natural substance ­isolated from a Chinese moss (Lycopodium serratum) has anticholine­sterase and neuroprotective activity (Drugs Aging 2003;20: 981-98).
• Vinpocetine, a substance derived from a natural constituent of the lesser periwinkle, has antioxidant, blood flow-enhancing, and other neuroprotective properties, and can reduce the loss of neurons due to decreased blood flow (Nutrition 2003;19:957-75).
• Vitamin E supplementation is associated with protection from oxidative damage to brain tissues (Ann N Y Acad Sci 2004;1031:249-62).
• Both folic acid and cobalamin (vitamin B12) are important for normal cognitive function in the elderly (Biol Psychiatry 1999;45:1472-80).

Supplement Facts Serving Size - 2 capsules Servings per container 60
Amount per serving:		%DV
Natural Vitamin E (d-alpha mixed tocopherols)	150 IU	500%
Vitamin B1 (thiamine HCl)	250 mg	16,667%
Vitamin B6 (pyridoxine HCl)	20 mg	1,000%
Folic Acid	400 mcg	100%
Vitamin B12 (cyanocobalamin)	1,000 mcg	16,667%
Acetyl-L-Carnitine	500 mg	†
Ginkgo (Ginkgo biloba)*	120 mg	†
Huperzine A	200 mcg	†
Vinpocetine	30 mg	†
† Daily Value (DV) not established

* Standardized to 24% ginkgo flavon glycosides and 6% terpene lactones

Other ingredients: cellulose, magnesium stearate, silicon dioxide

Suggested use for adults:

• Two capsules daily with meals, preferably morning and evening, or as directed.

MigraMAXX

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Advanced formula for stability of cerebral blood vessels and nerves

Product # 9139

90 capsules

Instability of cerebral blood vessels and nerves can lead to abnormal sensitivity of the tissues in and around the head. MigraMAXX contains three natural remedies for the prevention of these instabilities. Butterbur (Petasites hybridus), standardized for petasins content and processed to remove undesirable pyrrolizidine alkaloids, has emerged as a powerful influence on vascular tone and nerve sensitivity, partly through inhibiting effects on leukotriene synthesis. Magnesium participates in the regulation of vascular tone and reactivity by influencing platelet function, acting as a mild calcium channel blocker, and regulating the effects of serotonin and other neurotransmitters. Riboflavin may help correct certain mitochondrial dysfunctions related to instability of cerebral vasculature.

• Standardized butterbur extract contains petasin and isopetasin, which have spasmolytic, analgesic, and leukotriene-inhibiting properties (Altern Med Rev 2001;6:207-9).
• Several controlled clinical trials attest to the safety and effectiveness of standardized butterbur extract (Eur Neurol 2004;51:89-97; Neurology 2004;63:2240-4; Inter J Clin Pharmacol Ther 2000;38:430-435).
• Butterbur products guaranteed free of undesirable pyrrolizidine alkaloids are the preferred form of this remedy (Praxis-Telegram Nr. 1/98:13-14).
• Magnesium participates in the regulation of vascular tone and reactivity by influencing platelet function, acting as a mild calcium channel blocker, and regulating the effects of serotonin and other neurotransmitters (Persp Biol Med 1988;31:526-7).
• Magnesium supplementation helps increase days without head discomfort according to several controlled clinical studies (Headache 1991;31:298-301; Fortschr Med 1994;112:328-330; Cephalalgia 1996;16:257-263).
• Riboflavin, which may help correct certrain mitochondrial dysfunctions related to head discomfort, has also been effective in a controlled clinical study (Neurology 1998;50:466-70).

Supplement Facts Serving Size - 3 capsules Servings per container 30
Amount per serving:		%DV
Vitamin B2 (riboflavin)	200 mg	11,765%
Magnesium (glycinate)	600 mg	150%
Butterbur (Petasites hybridus )*	150 mg	†
† Daily Value (DV) not established

Other ingredients: vegetarian capsule, vegetable stearate

* Butterbur extract (15% [petasin + isopetasin]). Purified to remove toxic (PA) pyrolizidine alkaloids.

Suggested use for adults:

• One capsule, with meals, three times daily, or as directed.
  NOTE (especially for children): Limit to one capsule per day fore evry 50 pounds of body weight.

MigraPlex

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Feverfew and magnesium for stability of cerebral blood vessels and nerves

Product # 9140

90 capsules

Instability of cerebral blood vessels and nerves can lead to abnormal sensitivity of the tissues in and around the head. MigraPlex contains two well-researched natural remedies for the prevention of these instabilities. Feverfew herb contains chemical components with significant prostaglandin and serotonin-modifying effects on cerebral vasomotor and nerve activity. Dried whole feverfew leaf standardized for parthenolide content is the most reliable form of this botanical remedy. Magnesium participates in the regulation of vascular tone and reactivity by influencing platelet function, acting as a mild calcium channel blocker, and regulating the effects of serotonin and other neurotransmitters..

• Standardized feverfew leaf extract contains the active constituent parthenolide, which has been shown to maintain normal blood vessel tone by reducing the release of serotonin from platelets (Lancet 1985;1:1071-4).
• Feverfew inhibits the production and release of inflammatory chemicals such as prostaglandins and arachidonic acid (Prostagland Leukotrienes Med 1982;8:653-60).
• In addition to controlling platelet serotonin secretion, feverfew has been shown to reduce platelet aggregation (J Pharm Pharmacol 1990;42:553-7).
• Controlled clinical research has found feverfew effective for stabilizing cerebral vasomotor and nerve overactivity associated with certain musculoskeletal complaints (Cephalagia 1998;18:704-8).
• Magnesium participates in the regulation of vascular tone and reactivity by influencing platelet function, acting as a mild calcium channel blocker, and regulating the effects of serotonin and other neurotransmitters (Persp Biol Med 1988;31:526-7).
• Magnesium supplementation helps increase days without head discomfort according to several controlled clinical studies (Headache 1991;31:298-301; Fortschr Med 1994;112:328-330; Cephalalgia 1996;16:257-263).
  

Supplement Facts Serving Size - 3 capsules Servings per container 30
Amount per serving:		%DV
Magnesium (aspartate)	600 mg	150%
Feverfew (Tanacetum parthenium)**	100 mg	†
† Daily Value (DV) not established

Other ingredients: vegetarian capsule, vegetable stearate

** Dried whole leaf standardized to 0.5% parthenolide for a daily total of 500 mcg parthenolide

Caution: This product is not recommended for pregnant or lactating women.

Suggested use for adults:

• One capsule, with meals, three times daily, or as directed.

N-Acetyl-L-Cysteine

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Critical antioxidant and glutathione precursor, with specific support for healthy lung function

Product # 8111

180 capsules

N-Acetyl-Cysteine (NAC) is a precursor of the tripeptide glutathione, a critical antioxidant, with roles in xenobiotic detoxification, amino acid metabolism and immune defense. NAC acts as a mucolytic agent and thus assists normal respiratory function. By acting as a glutathione precursor, NAC helps maintain normal immune, liver and cardiovascular function.

• N-Acetyl-L-Cysteine (NAC) is a precursor of the tripeptide glutathione – a critical antioxidant, with roles in xenobiotic detoxification and amino acid metabolism. Glutathione depletion is characteristic of many conditions of impaired health (Curr Opin Clin Nutr Metab Care 1999;2:487-92).
• N-Acetyl-L-Cysteine (NAC) acts as a mucolytic agent and thus assists in restoring normal respiratory function (Clin Ther 2000; 22:209-21; Respiration 1999;66:495-500; Eur Respir J 1997;10:1535-41).
• By acting as a reliable oral glutathione precursor, NAC helps maintain normal immune, liver and cardiovascular function (Altern Med Rev 1998;3:114-27).

Supplement Facts Serving Size - 2 capsules Servings per container 90
Amount per serving:		%DV
N-Acetyl-L-Cysteine	1000 mg	†
† Daily Value (DV) not established

Other ingredient: rice flour

Suggested use for adults:

• 2 - 6 capsules per day, in divided doses between meals, or as directed.

NeuroRelax

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Relaxing formulation for optimum mental functioning

Product # 5125

120 capsules

The components of NeuroRelax act synergistically to support patients’ innate ability to achieve a calm, positive, energetic, and productive attitude. As secondary benefits, it contains herbs that improve the ability of people to cope with daily life challenges and enjoy good sleep. Its components are non-addictive and, unlike antidepressant medications, are not known to cause adverse effects on sexual function. NeuroRelax can be substituted for Piper methysticum (Kava) with patients who are considered inappropriate candidates for this herb. Though relaxing, this formula will actually tend to improve concentration and maintain mental functioning.

• Passionflower compared favorably with oxazepam because it calmed without impairing job performance (J Clin Pharm Ther 2001;26(5):363-7).
• Clinical studies show that Rhodiola rosea (Golden Root) helped physicians on night duty maintain alertness (Phytomedicine 2000;7:365-371), motivated medical students preparing for exams (Phytomedicine 2000;7:85–9) and reduced mental fatigue in military cadets (Phytomedicine 2003;10:95–105).
• Clinical studies with St. John's Wort extract (BMJ 1996;313:253-8) and DL-phenylalanine (Arch Psychiatr Nervenkr 1979;227:49–58) have demonstrated that these agents help support normal psychological mood.

Supplement Facts Serving Size - 4 capsules Servings per container 30
Amount per serving:		%DV
DL-Phenylalanine	500 mg	†
St. John's Wort (Hypericum perforatum)*	300 mg	†
Jujube Seed (Zizyphus jujuba)	200 mg	†
California Poppy (Eschscholzia californica)	200 mg	†
Passion Flower (Passiflora incarnata)**	200 mg	†
Skullcap (Scutellaria lateriflora)	200 mg	†
Golden Root (Rhodiola rosea)***	150 mg	†
† Daily Value (DV) not established

* Standardized to 3% hyperforin and .3% hypericin.
** Standardized to contain at least .4% flavonoids as hyperoside.
*** Standardized to 4 mg rosavin per 150 mg herb.

Other ingredients: vegetarian capsule, cellulose, silica, magnesium stearate

Warning: Do not use if pregnant, or with MAO inhibitors.

Suggested use for adults:

• Two capsules twice daily, away from meals, or as directed by your health practitioner.

Phosphatidylserine

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Powerful natural substance for optimal brain function

Product # 8108

90 capsules

Phosphatidylserine is the most abundant phospholipid in the brain and performs vital functions to support normal cognitive function. Phosphatidylserine has an enviable safety record: in human clinical experience over 15 years and many thousands of patients, not a single adverse event has been reported. The dose used in almost all human studies was 300 mg/day.

• Phosphatidylserine is the most abundant phospholipid in the brain and is vital for normal membrane function of cerebral neurons (Nutrition 1999;15:778-83).
• Administration of phosphatidylserine is thought to support normal neuronal function (Neurology 1991; 41:644-9) and adequate production of neurotransmitters (Psychopharmacol Bull 1992;28:61-6).
• Supplementary phosphatidylserine may promote normal brain function in older patients (Ageing (Milano) 1993;5:123-33).
• Phosphatidylserine may also play a role in stabilizing mood, according to preliminary clinical research (Acta Psychiatr Scand (Denmark) 1990;81:265-70).

Supplement Facts Serving Size - 3 capsules Servings per container 30
Amount per serving:		%DV
Phosphatidylserine*	300 mg	†
† Daily Value (DV) not established

* derived from soy

Other ingredients: vegetarian capsule, rice flour and magnesium stearate

Suggested use for adults:

• Three capsules daily, in divided doses, or as directed.

St. John’s Wort

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Standardized herbal extract for emotional well-being

Product # 5204

90 capsules

St. John’s Wort has emerged as the leading botanical product for enhanced mood and well-being. St. John’s Wort contains numerous substances, including hypericin, which have been shown to modulate neurotransmitter activity as well as other aspects of neuroendocrine function. Included in these effects are inhibition of both monoamine oxidase and serotonin reuptake. Extracts standardized for 0.3% hypericin content are routinely used in clinical studies of St. John’s Wort.

• St. John’s Wort (Hypericum perforatum) contains hypericin and related substances that modulate the activity of several neurotransmitters, including serotonin, norepinephrine and dopamine (Pharmacopsychiatry 2001;34:45-9; Ann Pharmacother 1998;32:1201-8).
• St. John’s Wort also contains flavonoids that also contribute to its neuroendocrine effects (Planta Med 2004;70:1008-11).
• Clinical studies with St. John’s Wort extract have demonstrated that this herb helps support normal psychological mood (Compr Psychiatry 2000;41 (2 Suppl 1):133-7; Arch Intern Med 2000; 160:152-6; BMJ 1996;313:253-8). .

Supplement Facts Serving Size - 1 capsule Servings per container 90
Amount per serving:		%DV
St. John's Wort (Hypericum perforatum )*	300 mg	†
† Daily Value (DV) not established

* Standardized to 0.3% hypericin

Other ingredients: rice flour, magnesium stearate and silicon dioxide

Caution: This product should not be combined with antidepressant medication.

Suggested use for adults:

• One capsule, 2-3 times daily, before meals, or as directed.

SAM-e Plus

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Enterically coated tablets with methylation and transulfuration co-factors

Product # 9124

30 tablets

tablets

Product # 9124

60 tablets

tablets

Over a decade of rigorous clinical studies in Europe and elsewhere have established SAM-e (S-adenosyl-L-methionine, an essential methylation and transulfuration cofactor) as a useful tool for supporting normal mood regulation, and joint and liver health. SAM-e increases cell membrane fluidity, up-regulates neurotransmitter receptor number, and enhances neurotransmitter receptor affinity. SAM-e supports healthy joints both by increasing the number of articular chondrocytes, and by stimulating the synthesis of protective sulfated proteoglycans therein. SAM-e also protects synovial cells against pro-inflammatory prostanoids, and blocks enzymes that degrade cartilage. SAM-e is a precursor of the critical antioxidant glutathione, a key molecule in the detoxification process in the liver. SAM-e Plus contains the tosylate form of SAM-e as used extensively in clinical trials, and includes several other ingredients found in studies to support and facilitate these functions. SAM-e Plus tablets are enterically coated, essential for preventing demethylation in the stomach.

• S-Adenosyl-L-Methionine (SAM-e) supports normal liver function by acting as a methyl donor, and by promoting the regeneration of sulfur-containing amino acids and glutathione which protect against oxidative stress and toxic substances (Aliment Pharmacol Ther 1993 Feb;7(1):21-8).
• SAM-e promotes the health of joints by stimulating the synthesis of proteoglycans in articular chondrocytes; SAM-e acts with minimal or no side effects on the gastrointestinal tract and other organs (Am J Med 1987 Nov 20;83(5A):60-5).
• SAM-e is a major source of methyl groups in the brain, and promotes normal brain function in subjects with mood irregularities (Acta Neurol Scand Suppl 1994;154:7-14).
• SAM-e Plus tablets are enterically coated, which is essential since oral SAM-e is largely demethylated in the stomach, thereby losing much of its unique character.
• SAM-e Plus includes additional nutrient factors essential for normal methylation functions (Proc Nutr Soc 1999;58:441-8, Am J Clin Nutr 1995;61:659S-665S).

Supplement Facts Serving Size - 2 tablets* Servings per container 15 or 30
Amount per serving:		%DV
B3 (niacinamid)	30 mg	150%
B6 (pyridoxin HCI )	2 mg	100%
Folic Acid	400 mcg	100%
B12 (cyanocobalamin)	20 mcg	333%
SAM-e (tosylate disulfate)	400 mg	†
Choline (bitartrate)	50 mg	†
† Daily Value (DV) not established

* Enterically coated tablets

Other ingredients: stearic acid, calcium sulfate, AC-DI-SOL, cellulose, vegetable coating

Kept refrigerated prior to shipping for your protection

Suggested use for adults:

• Two to four tablets daily, preferably morning and evening, or as directed.

Sleep Formula

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Synergistic botanical combination supporting restful sleep

Product # 5126

60 capsules

Sleep Formula synergistically combines several herbs that help support healthy sleep and a calm mood, both of which are essential for many aspects of daily functioning and comfort. Valerian, passion flower, skullcap, lemon balm, and hops have a long history of use to support healthy sleep. Double-blind clinical trials have shown some of these herbs, alone or in combination, to be as effective as more chemical-based agents, but without causing daytime sleepiness. These herbs have actually been shown to increase alertness, at least in part by improving sleep quality. They can also help support a calm mood and are documented to be nontoxic and free from side effects, even for children.

• Valerian, passionflower, skullcap, lemon balm and hops have traditionally been used to enhance sleep quality (Arch Gen Psychiatry 1998;55:1033-44).
• Valerian possesses several mechanisms for calming neuronal activity, including the potentiation of the effects of the relaxing neurotransmitter GABA (J Pharm Pharmacol 1999;51:505-12).
• Combining of valerian with either lemon balm (Psychopharmakotherapie 1996;3:123-30; Therapiewoche 1992;42:726–36) or hops (Eur J Med Res 2000;5:385-90; Wien Med Wochenschr 1998;148:291–298) has been effective for promoting sleep without side effects of daytime withdrawal or sedation.
• Sleep Formula is safe for use in all age groups, is not addictive, does not impair the ability to drive or operate machinery (Pharmacopsychiatry 1999;32:235–41; Zeits Allegmeinmed 1995;71:1215–21), and does not interact with alcohol or other drugs.

Supplement Facts Serving Size - 1 capsule Servings per container 60
Amount per serving:		%DV
Valerian (Valeriana officinalis)* Standardized from concentration of 0.8-1.0% Valerenic Acid	150 mg	†
Passionflower (Passiflora incarnata)** Standardized from 3.5-4.0% flavonoids as Isovitexin	150 mg	†
Skullcap (Scutellaria lateriflora)** 4:1 Standardized Extract	150 mg	†
Lemon Balm (Melissa officinales)** 4:1 Standardized Extract	75 mg	†
Hops (Humulus lupulus)*** Standardized from 5.2% bitter acid or 2.0% essential oils	75 mg	†
† Daily Value (DV) not established

* From organic or wildcrafted root
** From organic or wildcrafted leaf
*** From organic or wildcrafted strobiles

Other ingredients: rice flour, magnesium stearate

Suggested use for adults:

• 1-2 capsules one hour before bedtime, or as directed for sleep, or one capsule three times daily, or as directed for a calming effect..