About... The Cardiovascular Support Formulas

CoQ-10

Coenzyme Q-10 occupies a critical biochemical niche in cellular bioenergetics, allowing mitochondrial mechanisms to generate energy (ATP) (Biochim Biophys Acta 2004;1660:171-99). Coenzyme Q-10 is an important antioxidant, acting alone and by assisting in the regeneration of other antioxidants such as ascorbate and vitamin E (J Am Coll Nutr 2001;20:591-8). Coenzyme Q-10 is found most abundantly in actively respiring tissues such as the heart and skeletal muscles, whose function can be optimized by maintaining adequate levels of this nutrient (J Neurol 1998; 245:681-5; J Clin Pharmacol 1990;30:596-608). Based on extensive clinical research (Ugeskr Laeger 1997;159:7302-8; Clin Investig 1993;71:S116-23), physicians in Japan have long been recommending coenzyme Q-10 for support of the heart and circulatory system. Additional CoQ-10 has been shown to promote the health of epithelial tissues such as the gingiva (Res Commun Chem Pathol Pharmacol 1976;14:715-9), and may assist in the regulation of blood pressure (J Hum Hypertens 1999;13:203-8; Curr Ther Res 1990;47:841-5). Lipid-soluble delivery systems guarantee the highest bioavailability of oral coenzyme Q-10 supplements (Mol Aspects Med 1994;15:s273-80).

CoQ-10 30 mg

back to top

Lipid-soluble coenzyme Q-10 for support of mitochondrial function

Product # 6101

60 softgels

softgel

Coenzyme Q-10 occurs in cellular mitochondria throughout the body and is essential to their function and for ATP production. The areas of highest energy metabolism, including the heart and skeletal muscle, depend heavily on CoQ-10 for normal function and antioxidant protection. CoQ-10 levels decline with aging, and endogenous synthesis levels can also fall behind during times of high energy output, as well as in some disease states. A rapidly growing body of research has confirmed the participation of CoQ-10 in maintenance of blood pressure homeostasis, cardiovascular and brain function, and oral tissue health.

• Karuna CoQ-10 products are encapsulated in softgels which contain a lipid-soluble medium that helps maximize the absorption and utilization of Q-10.
• Tissue depletion of CoQ10 levels by statin medications and red yeast rice suggest it would be prudent for patients using these agents to supplement with a small amount of CoQ10 (Ann Pharmacother 2006;40:290-4).

Supplement Facts Serving Size - 1 softgel Servings per container 60
Amount per serving:		%DV
Vitamin E (d-alpha tocopherol)	5 IU	17%
Coenzyme Q-10	30 mg	†
† Daily Value (DV) not established

Other ingredients: rice bran oil, gelatin, glycerin, soy lecithin, yellow beeswax, titanium dioxide, annatto color

WARNING: If you are pregnant, nursing, taking any medications or planning any medical procedure, consult your doctor before use.

Suggested use for adults:

• 1-4 capsules daily, taken with meals, or as directed.

CoQ-10 100 mg

back to top

Concentrated lipid-soluble coenzyme Q-10

Product # 6105

30 softgels

softgel

Product # 6109

60 softgels

softgel

Coenzyme Q-10 occurs in cellular mitochondria throughout the body and is essential to their function and for ATP production. The areas of highest energy metabolism, including the heart and skeletal muscle, depend heavily on CoQ-10 for normal function and antioxidant protection. CoQ-10 levels decline with aging, and endogenous synthesis levels can also fall behind during times of high energy output, as well as in some disease states. A rapidly growing body of research has confirmed the participation of CoQ-10 in maintenance of blood pressure homeostasis, cardiovascular and brain function, and oral tissue health. All Karuna CoQ-10 products are presented in softgel capsules with vitamin E, as research strongly emphasizes that CoQ-10 needs a lipid-soluble medium for greater absorption and bioavailability. Note the selection of milligram amounts and softgel capsule counts for dosing flexibility.

• Increasingly, higher doses of coenzyme Q-10 are being shown to have superior effects. This formulation provides 100 mg per capsule, necessary in particular to achieve doses for optimal cellular health, immune system activity (Biochem Biophys Res Commun 1995;212:172-7), and normal heart (Am J Cardiol 1985; 56:247; Clin Investig 1993;71:S134-6) and brain function (Arch Neurol 2002; 59:1541–50).

Supplement Facts Serving Size - 1 softgel Servings per container 30 or 60
Amount per serving:		%DV
Vitamin E (d-alpha tocopherol)	5 IU	17%
Coenzyme Q-10	100 mg	†
† Daily Value (DV) not established

Other ingredients: rice bran oil, gelatin, glycerin, soy lecithin, yellow beeswax, titanium dioxide, annatto color

WARNING: If you are pregnant, nursing, taking any medications or planning any medical procedure, consult your doctor before use.

Suggested use for adults:

• 1-2 capsules daily, taken with meals, or as directed.

E-400

back to top

Natural mixed tocopherols for antioxidant protection and more

Product # 1205

90 softgels

softgel

• Vitamin E is the primary lipid-soluble antioxidant found in the body.
• Vitamin E supplementation may elevate the protective, high-density lipoprotein (HDL) cholesterol in some individuals, and reduce the susceptibility of low-density lipoprotein (LDL) cholesterol to oxidation.
• Some experimentatal and clinical evidence suggests that non-esterified vitamin E is utilized more efficiently by the body, maintaining high blood levels of vitamin E for longer periods than esterified forms.
• Vitamin E and other antioxidant micronutrients help maintain immunocompetence, especially in populations at risk such as the elderly.
• Vitamin E supplementation has a favorable influence on insulin sensitivity in healthy subjects, Type II diabetics and the elderly.

Supplement Facts Serving Size - 1 softgel Servings per container 90
Amount per serving:		%DV
Vitamin E (as d-Alpha Tocopherol plus d-Beta, d-Gamma, and d-Delta Tocopherols)	400 IU	1,333%

Suggested use for adults:

• 1-2 softgel capsule daily, taken with meals, or as directed.

Garlic

back to top

Odorless garlic, with stabilized bioavailable ingredients for cardiovascular health.

Product # 5215

120 tablets

tablets

Garlic has long been used in traditional health care. Modern garlic formulations have permitted stabilization of important precursor biochemicals while simultaneously reducing odor.

Karuna Garlic is a stable source of alliin, which is converted to the active form allicin in the intestine and absorbed into circulation.

Garlic has a host of benefits for the cardiovascular system including support for normal blood lipids, blood pressure, platelet function, preventing LDL oxidation, and stabilizing vessel walls. Garlic also has antimicrobial activity and supports optimal immune function.

• Garlic, especially when used as a standardized concentrate, has a favorable effect on blood lipids (Ann Int Med 1993;119:599–605), blood pressure (J Hyperten 1994;12:463–8) and platelet function (Arzneim-Forsch Drug Res 1993;43:119–22), and has been associated with long-term protection of the carotid arteries (Atherosclerosis 1999;144:237–49).
• Several components found in garlic supplements improve the resistance of LDL cholesterol to oxidation (J Nutr 2001;131:985S-8S).
• In vitro and animal studies suggest garlic has antimicrobial activity against potential intestinal pathogens such as Candida albicans and Helicobacter pylori (J Nutr 2001;131: 1106S-8S; Mycologia 1977;69:341–8; Br Vet J 1980;136:448–51).
• Garlic possesses properties that help optimize immune system and cellular defense functions (Environ Health Perspect 2001;109:893-902; Adv Ther 2001;18:189–193).

Supplement Facts Serving Size - 1 tablet Servings per container 120
Amount per serving:		%DV
Garlic (Allium sativum)*	650 mg	†
*Each tablet contains a minimum of the following:
Allicin	6,500 mcg/tab	†
Alliin	14,300 mcg/tab	†
gamma-Glutamylcysteines	5,800 mcg/tab	†
Total Thiosulfinates	6,500 mcg/tab	†
Sulfur	4,500 mcg/tab	†
† Daily Value (DV) not established

Other ingredients: magnesium stearate, stearic acid, vegetab enteric coating

Suggested use for adults:

• One tablet daily, or as directed.
• CAUTION: Consult your healthcare professional prior to use if you have or suspect a medical condition, are taking prescription drugs, or are pregnant or lactating.

Ginkgo

back to top

Standardized extract for support of memory function and healthy circulation

Product # 5202

60 capsules

Ginkgo biloba is an ancient plant whose constituents have numerous beneficial effects on nerve tissue and circulation. Support by Ginkgo biloba extract (GBE) for normal brain function is based on neuroprotective effects against agents that can promote neuronal degeneration as well as regulating effects on neuro–transmitters. Research also shows GBE to have profound effects on circulation through inhibition of platelet activating factor (PAF) and other mediators of blood viscosity. GBE has been demonstrated to promote cerebrovascular and peripheral vascular circulation, enhancing blood flow, glucose delivery and oxygenation throughout the body, especially to the brain and nerve cells. Karuna’s Ginkgo biloba extract (GBE) is standardized identically to specifications for extracts used in clinical trials.

• Ginkgo contains two important constituent groups – the ginkgo flavone glycosides and the terpene lactones.
• Ginkgo biloba's flavone glycosides act as potent free radical scavengers within the cardiovascular and central nervous systems (Life Sci 2000;67: 1389-96; Phytomedicine 1998;5:425-34).
• Ginkgo is well-known for its neuro-protective properties (Zeitschrift Phytother 1994;15:92-6) and its support of normal cerebral functions such as memory (Phytomedicine 2000;6:393-401; Lancet 1992;340: 1136-1139).
• Ginkgo biloba inhibits platelet activating factor (PAF) which, in excess, can contribute to imbalances in leukocyte activity, bronchial function, and circulatory supply to body tissues (Thromb Res 2002;108: 151-60; Arzneimittelforschung 1990;40:589–93).
• Ginkgo promotes normal circulation (Fortschr Med 1993;111 (10):170-2) and can increase pain-free walking ability in older patients with impaired circulation (Am J Med 2000;108:276-81).

Supplement Facts Serving Size - 1 capsule Servings per container 60
Amount per serving:		%DV
Ginkgo biloba Extract**	60 mg	†
† Daily Value (DV) not established

** Standardized from 20-24% ginkgo flavone glycosides and 6% terpene lactones

Other ingredients: vegetarian capsule, rice flour

Suggested use for adults:

• One capsule twice daily with morning and evening meals, or as directed.

GinkgoMag

back to top

Standardized Ginkgo biloba extract with magnesium for healthy circulation

Product # 5108

60 capsules

GinkgoMag combines two natural substances with effects on peripheral circulation. Ginkgo biloba extract (GBE) inhibits platelet activating factor (PAF), which reduces blood viscosity and relaxes the smooth muscle tissues of the blood vessels, respiratory tract and other organs. Magnesium affects vascular and bronchial tone through its participation in the regulation of neuromuscular electrical potentials and neurotransmission. Together, GBE and magnesium promote normal respiratory air flow and optimal cardiovascular and peripheral vascular circulation, facilitating blood flow, glucose delivery and oxygenation throughout the body, including the lower extremities and cardiac tissues.

• Ginkgo biloba is an ancient plant containing two important constituent groups – the ginkgo flavone glycosides and the terpene lactones. The Ginkgo biloba in GinkgoMag is standardized in relation to both ginkgo flavone glycosides (24%) and terpene lactones (6%).
• Ginkgo components facilitate optimal blood flow to all tissues by inhibiting platelet activating factor (PAF) activity and modulating the effects of neurotransmitters and endothelial-derived blood vessel relaxing factors (Thromb Res 2002;108:151-60; Fitoterapia 1998;49:195–244).
• Ginkgo promotes normal circulation (Fortschr Med 1993;111(10):170-2) and can increase comfortable walking ability in people with poor circulation (Am J Med 2000;108:276-81).
• Magnesium is required for ion transport across cell membranes to maintain neuromuscular electrical potentials and facilitate neuro-transmission (Clin Calcium 2005;15: 87-90, 255-60).
• Magnesium is important for normal vascular function and supports healthy blood pressure (Hypertension 1998;32:260-5) and optimal circulation (Circulation 2000;102: 2353-2358; Vasa 1985;14:285-8).
• Improved breathing comfort has been achieved with either supplemental ginkgo biloba (Chinese J Integrative
  & Western Med 1997;3:264–7) or magnesium (Magnesium Bulletin 1997;19:4–6; Eur Respir J 1997;10: 2225–9).

Supplement Facts Serving Size - 1 capsule Servings per container 60
Amount per serving:		%DV
Magnesium (amino acid chelate)	100 mg	25%
Ginkgo biloba extract**	60 mg	†
† Daily Value (DV) not established

** Standardized to 24% ginkgo flavone glycosides and 6% terpene lactones

Other ingredients: vegetarian capsule, magnesium stearate

Suggested use for adults:

• 1-2 capsules twice daily, or as directed.

Hawthorn

back to top

Standardized extract to support healthy cardiovascular function

Product # 5203

90 capsules

Hawthorn (Crataegus oxycantha) has been clinically demonstrated to prevent free radical damage to heart tissue and the cardiovascular system. It has also been shown to improve the efficiency of the heart by increasing blood supply to the heart muscle. Hawthorn also has the ability to inhibit angiotensin-converting enzyme (ACE), which is associated with increases in angiotensin II, a potent vasoconstrictor. As a result, the heart is able to pump more blood through the body, and circulation to the extremities is improved through lowered resistance to blood flow in peripheral vessels. Hawthorn exerts a gentle, measured effect on the heart and circulation, resulting in improved cardiovascular function.

• Hawthorn’s flavones increase contractions of the heart muscle, making it a more effective pump (Herz Gefabe 1993;11:516-24; J Cardiovasc Pharmacol 2000;35:700-7).
• Hawthorn reduces resistance in coronary and peripheral blood vessels and improves blood and oxygen flow to myocardial muscles (Arzneim-Forsch Drug Res 1967;17:490-1; ESCOP Phytotelegram 1994;6:20-6).
• Hawthorn has antioxidant properties and has been demonstrated to prevent free radical damage in heart tissue (Planta Med 1994;60:323-8; Arznei-mittelforschung 1997;47: 821-825).
• Numerous clinical studies have shown the ability of Hawthorn to support healthy heart muscle function, cardiac blood supply, and exercise tolerance (Fortschr Med 1996;114:291-6; Fortschr Med 1993;111:352-4; Therapiewoche 1983;33:4331-3).

Supplement Facts Serving Size - 1 capsule Servings per container 90
Amount per serving:		%DV
Hawthorn (Crataegus oxycantha )**	300 mg	†
† Daily Value (DV) not established

** Standardized to 1.8-2.2% vitexin (1.8-2.2% total flavonoids)

Other ingredients: rice flour

Suggested use for adults:

• One capsule 3 times daily, or as directed.

L-Carnitine

back to top

Mitochondrial energy and mycardial support

Product # 8106

120 capsules

gelatin

L-Carnitine is an important amino acid with a critical role facilitating the uptake of fatty acids into mitochondria for ­energy production. Cardiac muscle is rich in L-Carnitine, and inadequate amounts can affect this organ early on. Supplemental L-Carnitine supports normal myocardial energy production, stable cardiac rhythm, and normal oxygenation of myocardial and other tissues.

• L-Carnitine is required for long-chain fatty acid oxidation and is critical for muscle bioenergetics (J Am Coll Nutr 1998;17:207-15).
• Supplemental L-Carnitine may promote normal energy production, cardiovascular function, and lipid and glucose metabolism (Altern Med Rev 1998;3:345-60).
• Carnitine deficiency has been assoc-iated with conditions of impaired oxygen delivery (Lancet 1988;2:337; Cardiovasc Res 2001;51:21-9) and other chronic physiological impairments (J Diabetes Complications 1999;13:251-3).
• L-Carnitine supplements support maintenance of normal heart rhythm and overall function (Minerva Med 1989;80:227-31).
• Numerous studies indicate that L-Carnitine supplementation supports long-term myocardial health (Postgrad Med J 1996;72:45–50; J Am Coll Cardiol 1995;26:380–7; Drugs Exp Clin Res 1992;18:355–65).

Supplement Facts Serving Size - 1 capsule Servings per container 120
Amount per serving:		%DV
L-Carnitine (Acetyl L-carnitine)**	500 mg**	†
† Daily Value (DV) not established

** Microencapsulated **Yielding 500 mg of elemental Carnitine

Other ingredients: rice flour, silicon dioxide

Suggested use for adults:

• 1 - 4 capsules per day, in divided doses between meals, or as directed.

LipidOptimal™ new!

back to top

Addresses crucial deficiencies and risk factors as well as blood lipid levels.

Product # 9116

180 capsules

gelatin

A sound therapeutic approach combines natural ingredients that support circulatory health, reduce inflammation, and gently help normalize HDL/LDL levels, without the significant adverse effects of cholesterol-lowering drugs. Combined with a healthy diet and regular exercise, LipidOptimal™ can support achievement of long-term improvement in risk factors for premature death.

• Patients with low vitamin D levels had a 60% higher risk of a cardiovascular accident such as heart attack, heart failure or stroke even when cholesterol levels were taken into account. (Circulation 2006; 117:503-511.)
• Oyster mushrooms contain a wealth of vitamins and compounds that have a positive effect on circulatory health. (Z Naturforsch 2003; 30:470-475.)
• Kudzu is an ancient treatment for the heart in China and is used today in coronary artery disease and dyslipidemia. (Cochrane Database Syst Rev 2006; 19:CD004196; Zhongguo Linchuang Kangfu 2005; 9:183-185.)
• Pantethine, a natural derivative of coenzyme A, has a favorable effect on blood lipids demonstrated in many studies. (Atherosclerosis 1984; 50:73-83; Angiology 1987; 38:241-247.)
• Chromium supplementation, probably through effects on insulin function, often helps influence the production and metabolism of LDL and HDL cholesterol, as well as triglycerides. (J Adv Med 1995; 8:37-50.)
• Supplementary inositol hexaniacinate supports normal cholesterol and triglyceride levels (Artery 1980; 8:113- 119) and inhibits release of adipose fatty acids during sleep (Eur J ClinPharmacol 1979; 16; 11-15.)

Suggested use for adults:

Six tablets daily in divided doses, or as directed. Supplementation of CoQ-10 is recommended, as oyster mushroom components may lower tissue levels of CoQ-10. LipidOptimal should not be combined with chemotherapy drugs.

Overview

Synergistic formula supporting cardiovascular health and normal cholesterol metabolism

LipidOptimal employs natural cholesterol-lowering ingredients – Oyster Mushroom, Kudzu Root, the combination of Inositol Hexanicotinate (non-flushing niacin) and Chromium, and Pantethine – to support normal blood lipid levels. In a study, oyster mushrooms reduced total cholesterol by 28% and LDL by 55%. Kudzu also lowers blood viscosity and reduces the atherogenic effect of dietary cholesterol. Pantethine has been shown to raise HDL levels. Also included in LipidOptimal are Vitamin D, Vitamin E and Garlic. Vitamin D deficiency is associated with greater risk of atherosclerosis, heart attacks and stroke. LipidOptimal combines natural compounds with vitamins and minerals to gently and synergistically support the body’s innate ability to maintain appropriate levels of cholesterol, HDL, LDL and triglycerides. This progressive new Karuna formulation is responsive to current research challenging the concept that patients troubled by high cholesterol, low HDL or other issues of dyslipidemia should be treated with a single-minded focus on blood fat levels.

LipidOptimal, however, achieves other current-research-supported goals without the significant side effects of statin drugs.

LipiTonic

back to top

Complex of natural cholesterol and lipid metabolism modifiers for cardiovascular heatlh

Product # 9127

180 tablets

tablet

Lipitonic combines a comprehensive formula of vitamins, minerals and botanicals that specifically support normal lipid metabolism. Multiple interrelated mechanisms are targeted, including cholesterol synthesis, pathways of hepatic lipoprotein production, insulin function, and antioxidant protection. The B-complex vitamin niacin is present primarily as inositol hexaniacinate to reduce likelihood of flushing. Combined with a healthy diet and regular exercise, Lipitonic represents a safe, natural approach to maintaining normal blood lipid levels.

• Chinese red yeast rice extract contains compounds which modify cholesterol metabolism and may promote cardiovascular health (Am J Clin Nutr 1999;69:231-6).
• Supplementary inositol hexaniacinate supports normal cholesterol and triglycerides levels (Artery 1980;8(2): 113-9) and inhibits release of adipose fatty acids during sleep (Eur J Clin Pharmacol 1979;16:11-15).
• Pantethine, a natural derivative of coenzyme A, has a favorable effect on blood lipids demonstrated in many studies (Atherosclerosis 1984;50:73-83; Angiology 1987;38:241-7).
• Chromium supplementation, probably through effects on insulin function, often helps influence the production and metabolism of LDL and HDL cholesterol, as well as triglycerides (J Adv Med 1995;8:37-50).
• Supplementation with CoQ-10 is recommended, as red yeast rice components may lower tissue levels of CoQ10.
• Vitamin E supplementation may support optimal protective high-density lipoprotein (HDL) cholesterol level in some individuals (Isr J Med Sci 1987;23:869–72), and reduce the susceptibility of low-density lipoprotein (LDL) cholesterol to oxidation (Arterioscler Thromb 1993;13:1779–89).

Supplement Facts Serving Size - 6 tablets Servings per container 30
Amount per serving:		%DV
Vitamin E (natural d-alpha-tocopheryl acetate)	200 IU	667%
Vitamin B3 (niacin)	100 mg	500%
Chromium (picolinate)	400 mcg	333%
Red Yeast Rice (Monascus purpurea)	2000 mg	†
Inositol hexaniacinate	1500 mg	†
Pantethine	900 mg	†
Chlorophyll	300 mg	†
Allicin from Garlic (Allium sativum)	5 mg	†
† Daily Value (DV) not established

Other ingredients: magnesium stearate, silicon dioxide

Suggested use for adults:

• Six tablets daily in divided doses,
  or as directed. Supplementation of
  CoQ-10 is recommended, as red yeast rice components may lower tissue levels of CoQ-10.

MegaEPA

back to top

High potency fish oil concentrate for maximum omega-3 protection

Product # 4106

90 softgels

softgel

Product # 4107

180 softgels

softgel

MegaEPA provides the highest omega-3 fatty acid (EPA, DHA) concentration of any fish oil supplement commercially available, and research has shown EPA and DHA to specifically help maintain healthy blood pressure, blood lipid levels, platelet dynamics, and cardiac rhythm, all of which support cardiovascular health. As a result, the American Heart Association recommends regular intake of omega-3 fatty acids from fish to all people, and advises patients with heart disease to consider fish oil supplements. EPA and DHA also favorably enhance the balance of prostaglandins, thromboxanes, and leukotrienes to promote the health of numerous tissues and organ systems.

• Refer to About Fish Oil (see About Essential Fatty Acids).
• MegaEPA is a refined concentrate of natural marine oils which are a rich source of cholesterol-free polyunsaturated omega-3 fatty acids as stable esters.
• MegaEPA provides the highest omega-3 fatty acid concentration of any fish oil supplement commercially available.

MegaEPA - 1 capsule provides		%DV
Total Calories Calories from Fat	10.38 8.6
Total Fat Saturated Fat Trans Fats Unsaturated Fat Monunsaturated Fat Polyunsaturated Fat	955.46mg 75.51 mg 0 mg 879.95 mg 130.21 mg 749.74	1%
Cholesterol	5 mg	2%
Vitamin E (natural d-alpha tocopherol)	5 IU	17%
Marine Lipid Concentrate	1224 mg	*
Yielding:
EPA (Eicosapentaenoic Acid)	367.20 mg	*
DHA (Docoshexaenoic Acid)	244.80 mg	*
* Daily Value (DV) not established

% Daily values are based on 2000 calorie diet.

Kept refrigerated prior to shipping for your protection.

Suggested use for adults:

• 2-6 capsules in divided dosages, with meals, or as directed. It is recommended that people who take MegaEPA also supplement vitamin E in order to protect against oxidative damage.

NiaPlex

back to top

Flush-free B3 niacin/inositol complex plus chromium for healthy lipid metabolism

Product # 1208

60 capsules

Product # 1209

120 capsules

NiaPlex is a well-documented and effective natural combination for blood lipid control and blood sugar regulation. High-dose niacin supports normal blood levels of triglycerides as well as LDL and HDL cholesterol. Inositol hexaniacinate offers an alternative to ordinary niacin because it is a slow-release niacin ester, free from the “niacin flush” and its uncomfortable itching. Chromium enhances insulin action, has its own favorable effects on blood sugar and blood lipids, and is also synergistic with niacin in these actions.

• Hexaniacinate is a slowly-hydrolyzing inositol ester of niacin which offers the nutritional benefits of niacin without the flushing of high-dosage niacin (Alt Med Rev 1996;1:176-84).
• Niacin, especially in combination with chromium, can have a salutary effect on both lipid and carbohydrate metabolism (Postgrad Med 1995;98: 185-93); FASEB J 1991;5(6):A1645).
• Chromium facilitates the action of insulin, which in turn is needed for the normal control of blood sugar and blood lipids (J Amer Coll Nutr 1997; 16:404-10; J Nutr 1993;123:626-33).
• Clinical studies have found inositol hexaniacinate helpful for supporting normal circulation in the lower extremities (Br J Clin Pract 1988;42: 141-5; Br J Clin Pract 1988;42:377-83).

Supplement Facts Serving Size - 2 capsules Servings per container 30 or 60
Amount per serving:		%DV
Niacin (inositol hexaniacinate)	1,000 mg	5,000%
Chromium (chromium nicotinate)	200 mcg	166%

Other ingredients: vegetarian capsule, rice flour

Suggested use for adults:

• 2-4 capsules daily in divided doses, or as directed.

CAUTION: High doses of niacin, in any form, should be used only under supervision.

Tocotrienols

back to top

Full-spectrum vitamin E isomers

Product # 8110

60 capsules

softgel

In nature, vitamin E is a complex of eight molecular forms, four tocopherols and four tocotrienols; members of each group are identified as alpha, beta, delta, or gamma. Tocotrienols are also antioxidants, but are distinguished from tocopherols by several unique biochemical effects, including down regulation of HMG-CoA reductase (HMGCR), the key enzyme in cholesterol synthesis. Through antioxidant protection of lipoproteins and maintenance of healthy cholesterol regulation, tocotrienols help ensure optimal vascular capacity and blood flow. Tocotrienols also promote cellular health by inducing apoptosis, the natural mechanism of cellular growth control, in certain human cells. Karuna’s Tocotrienols is a balanced blend of both mixed tocotrienols and mixed tocopherols, the most complete vitamin E complex there is.

• Tocotrienols inhibit the rate-limiting enzyme of cholesterol biosynthesis (HMG-CoA reductase) and may thus support healthy blood cholesterol levels (Nutr Biochem 1997;8:290-8; J Med Chem 1992;35:3595-606); Am J Clin Nutr 1991;53:1021S–6S).
• Supplementary tocotrienols exert antioxidant effects in humans and help stabilize arterial capacity for normal blood flow (Lipids 1995;30: 1179-83).
• Tocotrienols induce apoptosis in certain human cells. Apoptosis is the natural mechanism of cellular growth control (Nutr Cancer 1999;33:26-32).

Supplement Facts Serving Size - 1 softgel Servings per container 60
Amount per serving:		%DV
Tocotrienols (NuTriene® Tocotrienols)	35 mg	†
† Daily Value (DV) not established

Other ingredients: rice, gelatin, glycerine, purified water

Suggested use for adults:

• 1 to 2 capsules daily, with meals, or as directed.

TriCard

back to top

Triple protection for cardiovascular health

Product # 6104

30 tablets

tablet

TriCard supplies antioxidant, homocysteine-lowering, and blood lipid benefits for the cardiovascular system. Complementary antioxidants help protection against oxidative damage to LDL cholesterol and other free radical insults. Appropriate B-vitamins facilitate catabolism of potentially hazardous homocysteine. Chromium and garlic are added to support favorable serum lipid levels and other cardiovascular benefits.

• TriCard provides antioxidants and metabolic stabilizers that have a role in protecting the heart and vascular system.
• Vitamin E supplementation has been associated with coronary artery health (Lancet 1996;347:781-6; Lancet 2000;356:1213-8) as well as long-term protection of the carotid arteries (J Intern Med 2000;248:177-86).
• Garlic, especially when used as a standardized concentrate, has a favorable effect on blood lipids (Ann Int Med 1993;119:599-605), blood pressure (J Hyperten 1994;12:463-8) and platelet function (Arzneim-Forsch Drug Res 1993;43:119-33), and has been associated with long-term protection of the carotid arteries (Atherosclerosis 1999;144:237-49). Folic acid and vitamins B6 and B12 have been shown to reduce and detoxify undesirable levels of the amino acid homocyst(e)ine, an atherogenic methionine derivative (J Nutr 1994;124:1927-33; Am J Cardiol 1995;75:132-6). Chromium adequacy can enhance insulin sensitivity and may reduce the tendency to hyperinsulinemia, which has an unfavorable effect on lipid metabolism and vascular health (J Am Coll Nutr 1998;17:548-55; J Am Coll Nutr 1997;16:404-10).
• Diets high in the flavonoid quercetin have been associated with cardioprotection in several studies (BMJ 1996;312:478-81; Arch Intern Med 1995;155:381-6).

Supplement Facts Serving Size - 1 tablet Servings per container 30
Amount per serving:		%DV
Vitamin C (ascorbic acid)	200 mg	333%
Vitamin E (natural d-alpha tocopheryl acetate)	400 IU	1333%
Vitamin B6 (Pyrodoxine HCI)	25 mg	1250%
Folic Acid	800 mcg	200%
Vitamin B12 (cyanocobalomine)	100 mcg	1667%
Selenium (L-selenomethionine)	100 mcg	143%
Chromium (chloride)	200 mcg	167%
Garlic (alium sativum)**	455 mg	†
Quercetin (a bioflavonoid)	50 mg	†
† Daily Value (DV) not established

** Equal to 10 mg alliin, from Pure Gar (deodorized garlic).

Suggested use for adults:

• One tablet daily, or as directed.

Venous Support

back to top

Natural support for impaired venous integrity and function

Product # 9134

90 capsules

Venous Support contains clinically-proven botanical and flavonoid combinations to support the connective tissue integrity of veins and capillaries. Optimal function of the venous circulatory system is essential for controlling fluid balance within the tissues of the upper and lower extremities, and to maintain normal volume of the leg and hemorrhoidal veins. Horse Chestnut Seed Extract contains escin, and Butcher’s Broom contains ruscogenins; these saponins are responsible for effects on vascular tone and permeability. The flavonoids diosmin and hesperidin, often combined with vitamin C, also have important influences on vascular connective tissue.

• Placebo-controlled trials have demonstrated the effectiveness of horse chestnut seed extract in alleviating the objective signs and subjective symptoms of impaired venous function (Arch Dermatol 1998;134:1356-60).
• In a case observation study involving 800 general practitioners and over 5,000 patients, horse chestnut extract produced dramatic improvement or complete relief of all symptoms of impaired venous function (Fortschr Med 1996;114:196-200).
• Randomized, controlled studies have shown that horse chestnut seed extract reduces symptoms of impaired hemorrhoidal vein integrity (Clin Ter 1978;86:545-59).
• Oral diosmin, a flavonoid, improves venous tone, vein elasticity, and other signs and symptoms in impaired venous function; the compound also accelerates leg ulcer healing (J Vasc Res 1999;36 Suppl 1:37-41).
• The combination of butcher’s broom (Ruscus aculeatus), hesperidin and ascorbic acid has been shown in a randomized multicenter study to be superior to another leading vasoactive medication in the treatment of impaired venous lymphatic function (Angiology 2000;51:535-44).

Supplement Facts Serving Size - 1 capsule Servings per container 90
Amount per serving:		%DV
Vitamin C (ascorbic acid)	100 mg	167%
Horse Chestnut (Aesculus hippocastanum)**	167 mg	†
Diosmin (micronized)	150 mg	†
Butchers Broom (Ruscus aculeatus)***	110 mg	†
Hesperidian methyl charcone	17 mg	†
† Daily Value (DV) not established

** Standardized to contain 33 mg aescin
*** 10% extract standardized to contain 11mg ruscogenins

Other ingredients: cellulose, magnesium stearate

Suggested use for adults:

• One capsule, three times daily away from meals