About... The Antioxidant Formulas

Carotenoids

Whereas beta-carotene has received more attention than other carotenoids, early research documenting the effects of high beta-carotene diets overlooked the fact that these diets were also high in other carotenoids (J Am Coll Nutr 1995;14:419-27). High doses of beta-carotene alone may reduce blood levels of other carotenoids (Am J Clin Nutr 2000; 71:950-5). All carotenoids have antioxidant activity, but some are deposited preferentially into specific body tissues, as in the affinity of lutein for the retina (Ann NY Acad Sci 1998;854:443-7; Int J Vitam Nutr Res 1998;68:349-53). Synthetic beta-carotene has failed to benefit health in several human clinical trials (Drug Saf 1999;21:253-66), whereas natural beta-carotene was studied in two trials with positive results (J Am Coll Nutr 1995;14:536 [abstr #48]; Ann Allergy Asthma Immunol 1999;82:549-53). Provitamin A carotenoids such as alpha- and beta-carotene represent excellent sources of vitamin A with no danger of vitamin A toxicity (Arch Biochem Biophys 2004;430:77-88). Lycopene, one of the most abundant carotenoids in the body, has been associated in human studies with optimum immune function (Proc Nutr Soc 1998;57:3A) and prostate health (Nutr Cancer 1999;33:159-64; Cancer Epidemiol Biomarkers Prev 2001;10:861–8). The xanthophylls, lutein and zeaxanthin, may play a special role in the health of the eyes; studies have found that their long-term intake appeared to support the health of the macula and the ocular lens (Optometry 2004;75:216-30; Nutrition 2003;19:21-4). Alpha-carotene and cryptoxanthin appear to confer preferential protection to lung tissue (J Natl Cancer Inst 1996;88:612-5; Cancer Epidemiol Biomarkers Prev 2001; 10:767-73).

Alpha Lipoic Acid

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Universal antioxidant supporting healthy glucose metabolism, nerve and eye tissues

Product # 6106

60 capsules

gelatin

Alpha Lipoic Acid (ALA) plays a key role in energy metabolism and acts as a multifunctional antioxidant in both water and lipid-soluble domains. ALA has been used for years in Europe for its ability to support normal glucose regulation and nerve and eye function. ALA also functions as a key intermediate in oxidative decarboxylation for energy producing reactions, and it facilitates enhanced antioxidant potential with glutathione, ascorbic acid and vitamin E.

• Alpha-lipoic acid (ALA) is often referred to as the “universal” antioxidant because it is both fat and water-soluble, it combats a wide variety of free radical reactions, and because it can regenerate other antioxidants back to their active state (Gen Pharmacol 1997;29:315-31; Free Rad Biol Med 1995;19:227-250).
• ALA is well-documented in human clinical research for its ability to support normal nerve function (Exp Clin Endocrinol Diabetes 1999; 107:421-30). ALA supplements also have direct benefits for blood sugar regulation according to human research (Diabetes Care 1999;22:280-7; Free Radic Biol Med 1999;27:309–14).
• Antioxidant protection of the eyes by ALA has been reported in both human (Vestn Oftalmol 1995;111:6-8) and animal (Biochem Biophys Res Commun 1996;221:422-429) studies.
• Animal research demonstrates that ALA can protect tissues from the damaging effects of oxygen deprivation (Brain Res 1996;717:184-188).

Supplement Facts Serving Size - 1 capsule Servings per container 60
Amount per serving:		%DV
Alpha Lipoic Acid (thioctic acid)	100 mg	†
† Daily Value (DV) not established

Other ingredients: cellulose, silicon dioxide, magnesium stearate

Suggested use for adults:

• 1-3 capsules, once or twice daily, taken with meals, or as directed.

C-1000

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Convenient, cost-effective form for easy compliance

Product # 1210

120 capsules

Vitamin C is known for its multiple essential and supportive roles in human health. Nobel-laureate Linus Pauling famously recommended plain ascorbic acid as the most efficient form for supplementing vitamin C. Karuna’s C-1000 supplies pure ascorbic acid in preservative-free vegetarian capsules for convenient use.

• See Vitamin Formulas.
• Ascorbic Acid provides a wide range of support for normal immune fuction, antioxidant protection, reproductive function, vascular and connective tissue stability, and urinary pH balance.
• Vitamin C supports immune function by elevating interferon levels and enhancing the activity of specific immune cells (Adv Nutr Res 1984;6:19–45; Pharmacology 1975;13:228).
• Vitamin C has antioxidant activity that helps neutralize free-radical reactions from sources such as secondhand smoke (Free Radic Biol Med 2000;28:428-36).

Supplement Facts Serving Size - 1 capsule Servings per container 120
Amount per serving:		%DV
Vitamin C (non-corn ascorbic acid)	1,000 mg	1,667%

Other ingredient: vegetarian capsule

Suggested use for adults:

• 1-3 capsules daily, or as directed.

C-Care Powder

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Buffered, hypoallergenic vitamin C powder from non-corn sources

Product # 1203

8 oz.

powder

C-Care Powder is a mildly effervescent blend of vitamin C and important minerals that permit a non-acidic formulation in a high-potency bulk powder convenient for use in generous amounts. The minerals in C-Care Powder help maintain a neutral pH environment that may lessen gastric sensitivity, and make a contribution to mineral requirements as well. Derived from non-corn sources, this formula is appropriate for use by most allergic and sensitive individuals.

• See Vitamin Formulas.
• Ascorbic Acid provides a wide range of support for normal immune fuction, antioxidant protection, reproductive function, vascular and connective tissue stability, and urinary pH balance.
• Vitamin C supports immune function by elevating interferon levels and enhancing the activity of specific immune cells (Adv Nutr Res 1984;6:19–45; Pharmacology 1975;13:228).
• Vitamin C has antioxidant activity that helps neutralize free-radical reactions from sources such as secondhand smoke (Free Radic Biol Med 2000;28:428-36).
• This effervescent, buffered vitamin C minimizes gastrointestinal upset and mineral leaching problems associated with liberal ascorbic acid supplementation.

Supplement Facts Serving Size - 1 teaspoon (5gm) Servings per container 46
Amount per serving:		%DV
Vitamin C (ascorbic acid)	2,600 mg	4,333%
Calcium (carbonate)	300 mg	30%
Magnesium (carbonate)	300 mg	75%
Zinc (gluconate)	5 mg	33%
Copper (gluconate)	500 mcg	25%
Potassium (carbonate)	35 mcg	1%

Suggested use for adults:

• One level teaspoon daily dissolved in water or juice, or as directed.
• Teaspoon equivalent to approximately 5gm

C-Plex

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Hypoallergenic vitamin C with bioflavonoids

Product # 1204

90 tablets

C-Plex, a non-corn based ascorbic acid with bioflavonoid concentrate, is a perfect hypoallergenic choice for supplementation with the vitamin C complex. Flavonoids such as rutin and hesperidin as well as those from citrus sources frequently occur with vitamin C in nature, and appear to improve its bioavailability and complement its actions in the body. Flavonoids are useful in their own right as antioxidants and stabilizers of vascular permeability and capillary integrity. C-Plex includes generous amounts of flavonoids, unlike many other vitamin C complex formulas.

• See Vitamin Formulas.
• Bioflavonoids and vitamin C have been used in human studies to facilitate normal reparative activities in various body tissues (Med Times 1962;90:529-32; Med Times 1960;88: 313-314).
• Flavonoids such as rutin and hesperidin, often combined with vitamin C, support normal vascular permeability and healthy capillary integrity (Int Angiol 1994;13:259–62; Int Angiol 1993;12:69–72; Delaware State Med J 1959;Jan:19–22; Am J Med Sci 1946;211:539–43).
• Ascorbic Acid provides a wide range of support for normal immune fuction, antioxidant protection, reproductive function, vascular and connective tissue stability, and urinary pH balance.

Supplement Facts Serving Size - 1 tablet Servings per container 90
Amount per serving:		%DV
Vitamin C (non-corn ascorbic acid)	500 mg	833%
Bioflavonoids (mixed citrus)	250 mg	†
Rutin	50 mg	†
Hesperidin Complex	50 mg	†

Other ingredients: cellulose, vegetable stearine

Suggested use for adults:

• One or more tablets daily, or as directed.

CoQ-10 30 mg

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Lipid-soluble coenzyme Q-10 for support of mitochondrial function

Product # 6101

60 capsules

softgel

Coenzyme Q-10 occurs in cellular mitochondria throughout the body and is essential to their function and for ATP production. The areas of highest energy metabolism, including the heart and skeletal muscle, depend heavily on CoQ-10 for normal function and antioxidant protection. CoQ-10 levels decline with aging, and endogenous synthesis levels can also fall behind during times of high energy output, as well as in some disease states. A rapidly growing body of research has confirmed the participation of CoQ-10 in maintenance of blood pressure homeostasis, cardiovascular and brain function, and oral tissue health.

• Karuna CoQ-10 products are encapsulated in softgels which contain a lipid-soluble medium that helps maximize the absorption and utilization of Q-10.
• Tissue depletion of CoQ10 levels by statin medications and red yeast rice suggest it would be prudent for patients using these agents to supplement with a small amount of CoQ10 (Ann Pharmacother 2006;40:290-4).

Supplement Facts Serving Size - 1 softgel Servings per container 60
Amount per serving:		%DV
Vitamin E (d-alpha tocopherol)	5 IU	17%
Coenzyme Q-10	30 mg	†
† Daily Value (DV) not established

Other ingredients: rice bran oil, gelatin, glycerin, soy lecithin, yellow beeswax, titanium dioxide, annatto color

WARNING: If you are pregnant, nursing, taking any medications or planning any medical procedure, consult your doctor before use.

Suggested use for adults:

• 1-4 capsules daily, taken with meals, or as directed.

CoQ-10 100 mg

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Concentrated lipid-soluble coenzyme Q-10

Product # 6105

30 capsules

softgel

Product # 6109

60 capsules

softgel

Coenzyme Q-10 occurs in cellular mitochondria throughout the body and is essential to their function and for ATP production. The areas of highest energy metabolism, including the heart and skeletal muscle, depend heavily on CoQ-10 for normal function and antioxidant protection. CoQ-10 levels decline with aging, and endogenous synthesis levels can also fall behind during times of high energy output, as well as in some disease states. A rapidly growing body of research has confirmed the participation of CoQ-10 in maintenance of blood pressure homeostasis, cardiovascular and brain function, and oral tissue health. All Karuna CoQ-10 products are presented in softgel capsules with vitamin E, as research strongly emphasizes that CoQ-10 needs a lipid-soluble medium for greater absorption and bioavailability. Note the selection of milligram amounts and softgel capsule counts for dosing flexibility.

• Increasingly, higher doses of coenzyme Q-10 are being shown to have superior effects. This formulation provides 100 mg per capsule, necessary in particular to achieve doses for optimal cellular health, immune system activity (Biochem Biophys Res Commun 1995;212:172-7), and normal heart (Am J Cardiol 1985; 56:247; Clin Investig 1993;71:S134-6) and brain function (Arch Neurol 2002; 59:1541–50).

Supplement Facts Serving Size - 1 softgel Servings per container 30 or 60
Amount per serving:		%DV
Vitamin E (d-alpha tocopherol)	5 IU	17%
Coenzyme Q-10	100 mg	†
† Daily Value (DV) not established

Other ingredients: rice bran oil, gelatin, glycerin, soy lecithin, yellow beeswax, titanium dioxide, annatto color

WARNING: If you are pregnant, nursing, taking any medications or planning any medical procedure, consult your doctor before use.

Suggested use for adults:

• 1-2 capsules daily, taken with meals, or as directed.

E-400

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Natural mixed tocopherols for antioxidant protection and more

Product # 1205

90 capsules

softgel

Vitamin E is the primary lipid-soluble antioxidant in human biology, required for free radical protection of structures having high lipid content such as cell and organelle membranes, lipoprotein particles, and the central nervous system environment. Clinical research has discovered specific functions of vitamin E for supporting immunocompetence, optimal circulation and joint health. E-400 is a natural extract and supplies not only the primary alpha-tocopherol vitamer, but also the beta-, delta-, and gamma-vitamers, in order to more closely match the variety of forms found in the diet. E-400 is also unesterified, making it suitable for external use as well.

• Vitamin E is the primary lipid-soluble antioxidant found in the body.
• Natural vitamin E may be as much as twice as bioavailable as synthetic E (Am J Clin Nutr 1994;60:397-402).
• Vitamin E supplementation may support optimal protective high-density lipoprotein (HDL) cholesterol level in some individuals (Isr J Med Sci 1987;23:869–72), and reduce the susceptibility of low-density lipoprotein (LDL) cholesterol to oxidation (Arterioscler Thromb 1993; 13:1779–89).
• Vitamin E and other antioxidant micronutrients help maintain immunocompetence, especially in populations at risk such as the elderly (JAMA 1997;277:1380–6).
• Antioxidant or other functions of vitamin E apparently have beneficial influences on joint health (Z Orthop 1986;124:340–3; Z Rheumatol 1990; 49:369–73).
• Clinical research has demonstrated that vitamin E supplements support healthy circulation in the lower extremities, which helps maintain normal walking endurance in the elderly (Int Clin Nutr Rev 1984;4: 178–82).

Supplement Facts Serving Size - 1 softgel Servings per container 90
Amount per serving:		%DV
Vitamin E (as d-Alpha Tocopherol plus d-Beta, d-Gamma, d-Delta Tocopherols)	400 IU	1,333%

Other ingredients: gelatin, glycerine, non-GMO soybean oil

WARNING: If you are pregnant, nursing, taking any medications, or planning any medical procedure, consult your doctor before use. KEEP OUT OF REACH OF CHILDREN.

Suggested use for adults:

• 1-2 softgel capsules daily, taken with meals, or as directed.

Grape Seed Extract

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Standardized extract containing oligomeric proanthocyanidins (OPCs)

Product # 5109

60 capsules

Grape Seed Extract provides a cost-effective concentrate of oligomeric proanthocyanidins (OPCs). OPCs are natural antioxidants but they also possess unique properties such as stabilizing and maintaining connective tissue integrity. Since connective tissue forms the basement membrane of body structures as diverse as eye tissues and blood vessels, OPCs have the potential to support clear vision, cardiovascular health, and normal interstitial fluid balance.

• Grape Seed Extract provides a cost-effective concentrate of grape seed flavonoids (GSFs), including oligomeric proanthocyanidins (OPCs), upon which this extract is standardized.
• Human research has documented the ability of grape seed extract supplements to boost total antioxidant activity measurable in the blood (J Clin Pharm Ther 1998;23:385-9) and to provide greater protection than combinations of other antioxidant nutrients (Ann N Y Acad Sci 2002;957:260-70).
• GSFs depress the activity of collagenase, the enzyme that degrades collagen, and have tonic effects on the capillaries and veins (Arzneimittelforschung 1994;44:592-601; Gazette Medicale 1985;92:96-100).
• Grape seed extract prevents changes in capillary permeability that could lead to accumulated fluid in the interstitial tissues (Ann Chir Polast Esthet 1984;29:393–5).
• The combination of antioxidant and connective tissue stabilizing effects of OPCs may be responsible for evidence of improved visual function in human studies of grape seed extract (Fitoterapia 1995;LXVI:291-317).
• GSFs have been shown by some studies to be among the protective agents in wine that provide wine-drinking populations with excellent cardiovascular health, in spite of diets rich in saturated fats and cholesterol (Clin Chim Acta 1996;246(1-2):163-82).
• GSFs have been shown to reduce LDL cholesterol oxidation and maintain normal arterial blood flow capacity in animal studies (Atherosclerosis 1999;142:139-49).
• A water extraction method of concentrating the grape seeds assures that no solvent residues remain after processing.

Supplement Facts Serving Size - 1 capsule Servings per container 60
Amount per serving:		%DV
Grape Seed Extract (BioVin®)**	50 mg	†
† Daily Value (DV) not established

** Yielding 47.5 mg of Oligomeric Proanthocyanidins

Other ingredient: rice flour

Suggested use for adults:

• One capsule, twice daily, or as directed.

Green Tea

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Powerful antioxidant support with a high potency green tea extract of 50% polyphenols

Product # 5110

90 capsules

Green Tea extract provides a standardized and extremely potent source of the catechin/polyphenol antioxidants, which have dramatically more free radical-quenching effects than other antioxidants. Research continues to indicate their promise for protecting structures such as membrane lipids and DNA as well as numerous tissues such as skin, joint cartilage, liver, neurons, and the cardiovascular system.

• The potent catechin/polyphenol antioxidants in green tea have been shown to protect fatty acids from free radical damage 20–200 times more efficiently than vitamin E (Cancer Lett 2000;153:1-5; Prev Med 1992;21:520-5).
• Green tea contains polyphenols such as epigallocatechin gallate (EGCG), which possess powerful antioxidant properties having numerous promising clinical applications (Prev Med 1992;21:334-50).
• High intake of green tea polyphenols is associated with good cardiovascular health (Ann Epidemiol 2000;10:401-8), liver health (BMJ 1995;310:693-6) and protection of DNA (Mutat Res 2002;512:37-65).
• Laboratory studies demonstrate that green tea polyphenols help protect cartilage by inhibiting proteoglycan and cartilage breakdown (J Nutr 2002;132:341-6; Proc Natl Acad Sci U S A 1999;96:4524-9) and blocking undesirable prostaglandin formation (Ann Nutr Metab 2004;48:151-5).
• Green tea polyphenols can protect neurons from oxidation and apoptosis (Life Sci 2001;70:603-14).

Supplement Facts Serving Size - 1 capsule Servings per container 90
Amount per serving:		%DV
Green Tea Extract*	500 mg	†
Providing: Cathechins/Polyphenols	250 mg	†
† Daily Value (DV) not established

* from Camellia sinensis standardized to 50%, and providing 250 mg catechins/polyphenols - contains less than 3% caffeine

Other ingredients: vegetarian capsules, vegetable stearine

Suggested use for adults:

• One capsule, three times daily with meals, or as directed.

Mixed Carotenoids

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Powerful antioxidant with lutein and lycopene

Product # 6107

30 capsules

Mixed Carotenoids is a broad spectrum carotenoid supplement containing natural alpha- and beta-carotenes combined with lutein, lycopene, zeaxanthin and cryptoxanthin. All carotenoids have antioxidant activity, but their activities vary depending on which tissues they are deposited into preferentially. Mixed carotenoid supplements protect against imbalances caused by excessive intake of only one member of this diverse phytonutrient family.

• Refer to Carotenoids above.
• Recent large dietary studies have suggested that intake of several carotenoids is associated with more powerful protection for cellular health than is the intake of single members of the carotenoid family (Am J Epidemiol 2002;156:536-547; Cancer Epidemiol Biomarkers Prev 2000;9:357-365).

Supplement Facts Serving Size - 1 capsule Servings per container 30
Amount per serving:		%DV
Natural Beta-carotene	25000 IU	†
Natural Alpha-carotene	4750 IU	†
Lutein (from marigolds)	5 mg	†
Lycopene (from tomatoes)	2.5 mg	†
Zeaxanthin	246 mcg	†
Cryptoxanthin	8 mcg	†
† Daily Value (DV) not established

Other ingredients: vegetarian capsule, cellulose, and magnesium stearate

Suggested use for adults:

• One capsule daily with meals, or as directed.

N-Acetyl-L-Cysteine

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Critical antioxidant and glutathione precursor, with specific support for healthy lung function

Product # 8111

180 capsules

N-Acetyl-Cysteine (NAC) is a precursor of the tripeptide glutathione, a critical antioxidant, with roles in xenobiotic detoxification, amino acid metabolism and immune defense. NAC acts as a mucolytic agent and thus assists normal respiratory function. By acting as a glutathione precursor, NAC helps maintain normal immune, liver and cardiovascular function.

• N-Acetyl-L-Cysteine (NAC) is a precursor of the tripeptide glutathione – a critical antioxidant, with roles in xenobiotic detoxification and amino acid metabolism. Glutathione depletion is characteristic of many conditions of impaired health (Curr Opin Clin Nutr Metab Care 1999;2:487-92).
• N-Acetyl-L-Cysteine (NAC) acts as a mucolytic agent and thus assists in restoring normal respiratory function (Clin Ther 2000; 22:209-21; Respiration 1999;66:495-500; Eur Respir J 1997;10:1535-41).
• By acting as a reliable oral glutathione precursor, NAC helps maintain normal immune, liver and cardiovascular function (Altern Med Rev 1998;3:114-27).

Supplement Facts Serving Size - 2 capsules Servings per container 90
Amount per serving:		%DV
N-Acetyl-L-Cysteine	1000 mg	†
† Daily Value (DV) not established

Other ingredient: rice flour

Suggested use for adults:

• 2 - 6 capsules per day, in divided doses between meals, or as directed.

OcuPlus

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High potency antioxidant formula for healthy eyes with bilberry and lutein

Product # 6108

60 capsules

Oxidative stress contributes significantly to the pathogenesis of common eye disorders in older Americans. OcuPlus is a broad spectrum formula combining antioxidant nutrients and botanicals associated with protection of eye structures.

• Individuals with low plasma concentrations of carotenoids and antioxidant vitamins are at increased risk for undesirable age-related changes in the eyes; carotenoids and antioxidant vitamins may help to retard some of these destructive processes (Am J Clin Nutr 1995 Dec;62:1448S-1461S).
• The xanthophylls, lutein and zeaxanthin, may play a special role in the health of the eyes; studies have found that their long-term intake appeared to support the health of the macula and the ocular lens (Optometry 2004;75:216-30; Nutrition 2003;19:21-4).
• The flavonoid quercetin inhibits aldose reductase, which may reduce accumulation of sorbitol byproducts in the ocular lens (Biochem Pharm 1976;25:2505-2513).
• Bilberry is high in anthocyanoside flavonoids that possess potent antioxidant activity, and show promise in protecting eye tissues from oxidative damage (Ann Ottamol Clin Ocul 1989;115:109; Ann Ottalmol Clin Ocul 1987;113:1173–7).
• Ginkgo biloba extract has an antioxidant, free-radical scavenger effect on the retina; it inhibits or reduces damage caused by oxidative insults (Int J Tissue React 1995;17:93-100).
• Taurine, a conditionally-essential sulfur amino acid, is found in high concentration in the retina, where it participates in photoreceptor function and provides protection from lipid peroxidation (Neurochem Res 2004;29:151-60; Nutr Rev 1975;33:343-7).

Supplement Facts Serving Size - 2 capsules Servings per container 30
Amount per serving:		%DV
Vitamin A (natural beta-carotene)	12,500 IU	250%
Vitamin C (ascorbic acid)	500 mg	833%
Vitamin E ( natural d-alpha-tocopheryl acetate)	200 IU	667%
Vitamin B2 (riboflavin)	50 mg	2941%
Selenium (L-seleniomethione)	100 mcg	143%
L-Taurine	500 mg	†
Bilberry Extract (Vaccinium myrtillus)**	180 mg	†
Quercetin (a bioflavonoid)	100 mg	†
Ginkgo biloba Extract***	60 mg	†
Lutein (from marigolds)	10 mg	†
Zeaxantin	500 mcg	†
† Daily Value (DV) not established

** Standardized to contain 25% anthocyanidins
***Standardized to 20–24% ginkgo flavone glycosides and 6% terpene lactones.

Other ingredients: vegetable stearine, cellulose

Suggested use for adults:

• 2 to 4 capsules daily, taken with meals, or as directed.

OxyGuard

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High potency protection against free radicals with natural mixed carotenoids

Product # 6102

90 capsules

OxyGuard provides a broad and synergistic spectrum of antioxidant activity. Antioxidants work best in combination, helping to regenerate one another. Combinations also avoid the potential for depletion of some antioxidants, particularly carotenoids, which may occur if a balanced mix is not used. Vitamins C, E, and selenium appear to be particularly synergistic. The addition of natural mixed carotenoids, and quercetin further improves the radical quenching effect of OxyGuard.

• Refer to Carotenoids above.
• OxyGuard’s formula includes natural-source beta carotene, alpha carotene, lutein, lycopene and other carotenoids balanced much as they occur in a diet of natural foods.
• OxyGuard contains a highly bioavailable form of selenium (J Nutr Sci Vitaminol 1999;45:119–28) that has been associated with impressive health protective effects in human studies (JAMA 1996;276:1957–63; Eur J Cancer 2000;36:694-709).
• Quercetin, an antioxidant from the flavonoid family, increases the free radical scavenging ability of the blood (Free Radic Res 1999;31 Suppl:S75-80) and is associated with coronary vascular health (BMJ 1996;312:478-81).

Supplement Facts Serving Size - 3 capsules Servings per container 30
Amount per serving:		%DV
Vitamin C (ascorbic acid)	1000 mg	1667%
Vitamin E ( natural d-alpha-tocopheryl acetate)	400 IU	1333%
Selenium (L-selenomethionine)	200 mcg	286%
Natural Beta-carotene	20,000 IU	†
Alpha-carotene	4,750 IU	†
Quercetin (a bioflavonoid)	35 mg	†
Lutein (from marigolds)	10 mg	†
Lycopene (from tomatoes)	6 mg	†
Zeaxanthin	493 mg	†
Cryptoxanthin	16 mcg	†
† Daily Value (DV) not established

Other ingredients: microcrystalline cellulose, vegetable stearine

Suggested use for adults:

• Three capsules daily, or as directed.

OxyPro

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Broad support for antioxidant enzymes plus free radical quenchers

Product # 6103

60 capsules

OxyPro is formulated with a base of free radical-quenching nutrients, plus additional vitamins, trace minerals and amino acids required for activation of the radical-scavenging enzymes superoxide dismutase (SOD) and glutathione reductase (GPx). This formula offers a more reliable approach to antioxidant enzyme support than enzyme-containing formulas having questionable absorption.

• Refer to Carotenoids above.
• Natural beta-carotene possesses superior antioxidant activity compared to the synthetic beta-carotene more commonly found in vitamin supplements (Amer J Clin Nutr 1996;63:729-34).
• In a controlled trial, a combination of supplemental beta-carotene and vitamins A, C and E helped protect myocardial tissue from the effects of ischemia (Am J Cardiol 1996;77:232-6).
• Zinc, copper and manganese are required for activation of superoxide dismutase (SOD), the enzyme responsible for scavenging harmful free radicals (FASEB J 1987;1:441-5). Superoxide dismutase itself is not effectively absorbed as an oral supplement (Am J Clin Nutr 1983; 37:5-7; Biopharm Drug Dispos 1996; 17:165-74).
• Selenium, the mineral activator of glutathione peroxidase, has been associated with cardioprotective effects (Int J Epidemiol 1990;19:918-22) and other long-term health benefits (J Natl Cancer Inst 1998; 90:1219-24).
• N-Acetyl-L-Cysteine, L-methionine, and glutathione are sulfur amino acids that participate in antioxidant mechanisms utilizing donor electrons available on sulfur atoms (Clin Sports Med 1999;18:525-36; Altern Med Rev 1998;3:114-27).

Supplement Facts Serving Size - 2 capsules Servings per container 30
Amount per serving:		%DV
Vitamin A (palmitate)	3,000 IU	60%
Vitamin C (ascorbic acid)	500 mg	833%
Vitamin E (natural d-alpha tocopheryl acetate)	300 IU	1000%
Zinc (citrate)	10 mg	67%
Selenium (L-selenomethionine)	75 mcg	107%
Copper (aspartate)	1 mg	50%
Manganese (aspartate)	5 mg	250%
Natural Beta-carotene	17,000 IU	†
N-acetyl-L-Cysteine	75mg	†
L-Methionine	40 mg	†
L-Glutathione	40 mg	†
Riboflavin 5'-phosphate	10 mg	†
Proanthocyanidins (grape seeds)	10 mg	†
† Daily Value (DV) not established

Other ingredients: vegetarian capsule, vegetable stearine, silica

Suggested use for adults:

• Two capsules daily, taken with meals, or as directed.

Tocotrienols

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Full-spectrum vitamin E isomers

Product # 8110

60 capsules

softgel

In nature, vitamin E is a complex of eight molecular forms, four tocopherols and four tocotrienols; members of each group are identified as alpha, beta, delta, or gamma. Tocotrienols are also antioxidants, but are distinguished from tocopherols by several unique biochemical effects, including down regulation of HMG-CoA reductase (HMGCR), the key enzyme in cholesterol synthesis. Through antioxidant protection of lipoproteins and maintenance of healthy cholesterol regulation, tocotrienols help ensure optimal vascular capacity and blood flow. Tocotrienols also promote cellular health by inducing apoptosis, the natural mechanism of cellular growth control, in certain human cells. Karuna’s Tocotrienols is a balanced blend of both mixed tocotrienols and mixed tocopherols, the most complete vitamin E complex there is.

• Tocotrienols inhibit the rate-limiting enzyme of cholesterol biosynthesis (HMG-CoA reductase) and may thus support healthy blood cholesterol levels (Nutr Biochem 1997;8:290-8; J Med Chem 1992;35:3595-606); Am J Clin Nutr 1991;53:1021S–6S).
• Supplementary tocotrienols exert antioxidant effects in humans and help stabilize arterial capacity for normal blood flow (Lipids 1995;30: 1179-83).
• Tocotrienols induce apoptosis in certain human cells. Apoptosis is the natural mechanism of cellular growth control (Nutr Cancer 1999;33:26-32).

Supplement Facts Serving Size - 1 softgel Servings per container 60
Amount per serving:		%DV
Tocotrienols (NuTriene® Tocotrienols)	35 mg	†
† Daily Value (DV) not established

Other ingredients: rice, gelatin, glycerine, purified water

Suggested use for adults:

• 1 to 2 capsules daily, with meals, or as directed.